At an unknown time period, the Pilot piloted the Derelict that was carrying thousands of Xenomorph eggs within its cargo bay for transport. One of the eggs hatched and the facehugger impregnated the Pilot, causing the Derelict to crash on planetoid LV-426. The Pilot activated a warning signal just before the embryo within it burst out of its chest.
In the year 2122, while returning from a job in the Solomons, the USCSS Nostromo was diverted to the Zeta II Reticuli system, Nostromo's onboard computer, MU-TH-UR 6000, intercepted a distress beacon originating from the planetoid LV-426 and awakened the crew prematurely from their hypersleep. The crew responded to the beacon and took Nostromo to the planetoid. a three-person survey crew explored the planetoid's surface where they came across a derelict spacecraft. Upon entering the ship, they discovered the fossilized remains of the Pilot and the Xenomorph eggs that were stored within the ship. Kane was impregnated by a facehugger and was taken back to the Nostromo for medical treatment, only to die a few hours later when the Xenomorph that was impregnated within him grew and burst violently out of his chest during the crew's last supper together. The creature quickly matured into an adult and began killing the crewmembers one by one, culminating in a series of events that led to the destruction of the Nostromo.
57 years later, in 2179, the terrafroming colony Hadley's Hope established on LV-426 was given a vague order from Weyland-Yutani executive Carter J. Burke to locate the derelict Engineer ship, having learned of the ship's location from the claims of Nostromo's sole survivor Ellen Ripley. Surveyors Russ and Anne Jorden located the ship; Russ was attacked by a facehugger and Anne pulled him out and radioed for help. Some of the rescue party also went into the Derelict and were attacked. All of the victims were returned to the colony, which eventually led to its downfall.